Ingabe ufuna ukuba nengqondo ecacile nejabulisayo? Ama-probiotics angasiza
Ngokwesithangami sesayensi esikhishwe yiWorld Health Organisation (WHO) ngoMashi 2022, ubhubhane lwe-COVID-19 luholele ekwenyukeni kwamazinga okukhathazeka nokucindezeleka emhlabeni wonke, afinyelela ku-25%. Lokhu kuholele ngokuqondile ekutheni u-2023 ube unyaka wokuthuthuka okusheshayo ekuzinakekeleni kwabathengi, ngesidingo esikhulayo "sokwelapha umzimba nengqondo." Idatha evela ku-National Bureau of Statistics ikhombisa ukuthi isilinganiso samahora okusebenza ezisebenzi e-China siye sakhuphuka kancane kancane, sifinyelela emahoreni angama-48.7 ngesonto ngoMashi 2023. Ukucindezeleka okuhlobene namahora okusebenza amade kungene kuzo zonke izici zokuphila kwansuku zonke.
I-"2023 National Health Insight Report - Family Health Edition," esanda kukhishwa yi-Dingxiang Doctor Data Research Institute, iphinde ibonise ukuthi "izinkinga zemizwelo" zikleliswe endaweni yesibili phakathi kwezinkinga zempilo ngonyaka odlule, ziphinde zibangele uchungechunge lwezinkinga ezihlobene, okuhlanganisa isimo esibi sesikhumba, ukuphazamiseka kokulala, nokulahlekelwa izinwele, nokukhathazeka okukhulayo ngalezi zinkinga zempilo ngokuya kwanda. Njengamanje, iningi lentsha libanjwe umjikelezo ononya wokucindezela okukhulu komsebenzi, ukungaphatheki kahle ngokomzwelo, ukuqwasha, nokungalali kahle.
Izindlela lapho ama-probiotics athonya ukuziphatha kobuchopho
Njengoba intshisekelo ku-gut microbiome iqhubeka nokukhula, ucwaningo oluningi luveze ukuthi i-gut microbiome iyingxenye ebalulekile yokulawula ukusebenza kobuchopho nokuziphatha. I-athikili eyanyatheliswa ngo-2022 ku-Lancet Gastroenterology & Hepatology yahlola izindlela ama-probiotics athinta ngazo impilo yobuchopho nokuphazamiseka kwengqondo (i-microbiome-gut-brain axis), ngokugxila kakhulu esimweni samanje socwaningo lomtholampilo mayelana nokusetshenziswa kwama-probiotics ekwelapheni ukuphazamiseka kwengqondo okunjengokucindezeleka nokukhathazeka.
Kuze kube manje, i-microbiome ixhumana kabili nobuchopho nge-microbiome-gut-brain axis (MGB). Ngokusho kwezincwadi ezishicilelwe, lokhu kuxhumana kwenzeka ngokuyinhloko ngezindlela ezintathu:
1. Izindlela Zemizwa Kuhlelo Lwezinzwa
Amathumbu agcina i-enteric nervous system (ENS), inethiwekhi ye-neural evumela amathumbu ukuthi asebenze ngaphandle kweziqondiso zobuchopho. Umhlanganyeli oyinhloko kulokhu kukhulumisana okuphindwe kabili kubonakala sengathi i-vagus nerve-enye yezinzwa ezinde kakhulu emzimbeni womuntu, ezixhuma ngokuqondile ubuchopho kanye namathumbu.
2. Izindlela ze-Neuroendocrine
Izindlela ze-neuroendocrine zibandakanya izithunywa ezinjengamahomoni nama-neurotransmitters. Ama-hormone okucindezeleka avame kakhulu i-adrenaline ne-cortisol, kokubili okubhekwa njengezinkomba zokucindezeleka. Ama-Neurotransmitters, okuhlanganisa i-gamma-aminobutyric acid (GABA) ne-serotonin, anganciphisa izimpendulo zokucindezeleka, akhuthaze ukuphumula kwengqondo.
3. Izindlela Zamasosha omzimba
Ithumbu liyisitho sokuzivikela esikhulu kunazo zonke emzimbeni womuntu, futhi ngaphezu kwama-70% wezinto zokuzivikela ezigxile lapho, okunomthelela cishe ku-80% wokumelana nomzimba. Lapho amasosha omzimba ethola izinsongo ezingaba khona noma azabalaza ukulondoloza isimo esinempilo, izindlela zokuzivikela ezifweni zibonisa ubuchopho, ikakhulukazi lapho zizwa izimpawu ezivela emathunjini. Ukusekela amasosha omzimba ngokusebenzisa amathumbu kubonakala kuyisu eliyisisekelo lokulondoloza impilo engokomzwelo.
I-Serotonin, i-endo native "hormone yenjabulo" ezalwa emathunjini
I-Serotonin (5-HT), eyaziwa nangokuthi i-5-hydroxytryptamine, iyi-monoamine neurotransmitter kanye nehomoni. Njenge-neurotransmitter, i-serotonin idlulisela ulwazi phakathi kwamangqamuzana ezinzwa ebuchosheni (uhlelo lwezinzwa olumaphakathi) nakuwo wonke umzimba (uhlelo lwezinzwa lwe-peripheral). Ngokuphawulekayo, cishe i-90% ye-serotonin itholakala kumaseli amathumbu, futhi i-10% kuphela ekhiqizwa ebuchosheni.
Ucwaningo lwamanje lubonisa ukuthi i-serotonin idlala indima ebalulekile ekulawuleni isimo sengqondo, ukukhathazeka, ukulala, izinga lokushisa lomzimba, isifiso sokudla, ukuziphatha ngokobulili, ukunyakaza, ukusebenza kwenhliziyo nemithambo yegazi, nokuqonda ubuhlungu, okwenza kube i-neurotransmitter ebalulekile ehilelekile ezinguqukweni ze-pathological ezihlobene nokuphazamiseka kwengqondo. Umthelela wayo ubonakala ikakhulukazi ekulawuleni isimo sengqondo nokulala:
Isimo: I-Serotonin ebuchosheni ivame ukubizwa ngokuthi ikhemikhali yemvelo "yokuzizwa ujabule", ethuthukisa ukugxila, ukuzinza kwemizwelo, kanye nenjabulo iyonke. Abantu abanamazinga aphansi e-serotonin basengozini enkulu yokucindezeleka, ukuziphatha okungalawuleki, ukusebenzisa kabi izidakamizwa, ukuthambekela kokuzibulala, ulaka nobudlova. Imithi eminingi esetshenziselwa ukwelapha ukukhathazeka, ukucindezeleka, nokunye ukuphazamiseka kwemizwelo ngokuvamile ihlose ukuphakamisa amazinga e-serotonin ebuchosheni, njenge-antidepressant fluoxetine hydrochloride.
Ukulala: I-Serotonin, ihlangene nenye i-neurotransmitter, i-dopamine, idlala indima ebalulekile kukho kokubili izinga lokulala nobude besikhathi. Ubuchopho budinga futhi i-serotonin ukuze bukhiqize i-melatonin, i-hormone elawula umjikelezo wokulala.
Kubalulekile ukuqaphela ukuthi ngokukhula, ukusebenza kahle kwezindlela ze-serotonin kuyehla ngenxa yokuncipha kwenani lama-serotonin receptors acushiwe. Ucwaningo lukhombisa ukuthi inani lama-serotonin-specific receptors ebuchosheni babantu abaneminyaka engama-60 uma kuqhathaniswa nalabo abaneminyaka engama-30 lehle ngo-60%. Lokhu kwehla kokusebenza kwe-serotonin kuhlotshaniswa namathuba akhulayo okuthuthukisa ukudangala njengoba unyaka owodwa.
Ukwengeza, i-serotonin ithuthukisa inkumbulo futhi ivikele ama-neurons emonakalweni obangelwa izinto "excitotoxic". Ngakho-ke, ukulondoloza amazinga anele e-serotonin kubalulekile ekuvimbeleni ukulimala kobuchopho phakathi nenqubo yokuguga.
Kubalulekile ukulondoloza amandla omzimba okukhiqiza i-serotonin!
Izinhlobo zobungcweti zamagciwane akhiqiza i-5-hydroxytryptamine zithuthukisa "amandla enjabulo" awo.
I-BioyitechI-Bifidobacterium animalis subsp.lactis F1-7 kanye ne-Lacticaseibacillus paracasei X11 ilawula ukuphuma kwamathumbu e-5-hydroxytryptamine ngokusebenzisa izindlela zokubonisa i-catecholamine kanye nokuphuma kwe-short-chain fatty acids.
Amazinga e-tryptophan eqenjini lamamodeli ayephakeme kakhulu kunalawo aseqenjini elivamile (p
I-5-HT4GPCR iphrotheni yesamukeli ekwazi ukuzwa i-serotonin. Ngemva kokuphatha ukwakheka kwe-KGM + F1-7 nge-enema, kube nokwanda okuphawulekayo kokuvezwa kofuzo lwe-5-HT4GPCR.
Ukubhekwa kukhombisa ukuthi i-X11 ingathuthukisa kakhulu ukuvezwa kwe-serotonin, ngokwenyuka kwe-SERT okuqinisekisa ukukhuphuka kwamazinga e-serotonin emzimbeni, ngaleyo ndlela kube nemiphumela engokomzimba.
Idatha yokuhlola ibonisa ukuthi zombili i-subspecies F1-7 ye-Bifidobacterium animalis kanye ne-X11 I-Lactococcus i-lactis ingakhuphula ukuvezwa kwe-5-hydroxytryptamine nama-receptors ayo kuye noma eduze kwamazinga ajwayelekile.
Sekukonke, ama-probiotics angathuthukisa "izinto zenjabulo" ezingapheli, aphephile, angabizi kakhulu, futhi awahlukumezeki kangako ngokwengqondo uma kuqhathaniswa nokwelapha okungokwesiko kokuphazamiseka kwemizwa; nokho, umqondo usalokhu uyinoveli uma kuqhathaniswa. Silindele ukuthi izifundo ezilawulwa ngezinga elikhulu esikhathini esizayo zizoveza imininingwane emisha, ikakhulukazi mayelana nokwengezwa kwama-probiotics "enjabulo" ezixukwini ezinezimpendulo ezinganele zokwelashwa okujwayelekile noma lezo ezibonisa ukumelana nezidakamizwa.